Cisplatin livertox
Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl…
Cisplatin livertox
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WebCisplatin, doxorubicin and fluorouracil (5-FU), drugs belonging to different chemical classes, have been extensively used for chemotherapy of various cancers. Despite extensive investigations into their hepatotoxicity, there is very limited information on their effects on the structure and ultra-structure of liver cells in vivo. WebMar 30, 2024 · LiverTox®provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury …
WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose … WebCarboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich …
WebLiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012 In vitro phase II comparison of the cytotoxicity of a novel platinum analog, nedaplatin (254-S), with that of cisplatin and carboplatin against fresh, human ovarian cancers. [Cancer Chemother Pharmacol. 1997] WebIn combination with cisplatin for first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) As a single agent for the treatment of …
WebJan 1, 2013 · LiverTox has three major components: (1) introductory sections that describe DILI, including the course, diagnosis, clinical phenotypes of injury, immunological …
WebMaterials. Cisplatin (Cisplatyl 50 mg, Laboratoire Roger Bellon) was a generous gift from NCI drug store. Silymarin was purchased from Aldrich Chemical Co. The required dose was dissolved in 0.2 ml of propylene glycol in saline 75/25 (v/v) (Mereish et al ., 1991). Experimental design. Cisplatin treatment protocol used in this seth rumley dds raleigh ncWebApr 5, 2024 · LiverTox® provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury … the three horseshoes warhamWebJun 23, 2024 · Durvalumab is a human monoclonal antibody to programmed cell death ligand 1 (PD-L1), which acts as a checkpoint inhibitor and is used in the immunotherapy of several forms of advanced … the three horseshoes tiptonWebMay 18, 2024 · Cisplatin (cis-diamminedichloroplatinum; CP) is an effective alkylating and antineoplastic agent that is widely used in the treatment of solid tumors. 1 The liver is a key organ in the metabolism and detoxification of endobiotics and xenobiotics. 2 CP is accumulated in liver cells, leading to hepatotoxicity. the three horseshoes waltham abbeyWebMar 9, 2024 · A typical dosing regimen is 30 minute infusions of 1.0 to 1.2 g/m 2 on days 1, 8 and 15 of each 28 day cycle of chemotherapy. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, … seth rush ddsWebNational Center for Biotechnology Information the three horseshoes warham menuWebThe DILIrank dataset consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI). The DILI classification is ... the three horseshoes warham norfolk