WebMar 7, 2024 · As enzymes that mediate the attachment of long-chain fatty acids to cysteine residues, ZDHHC proteins have been reported to be promising therapeutic targets for treating cancer and autoimmune diseases. Yet, due to the lack of potent selective inhibitors, scrutiny of the biological functions of ZDHHCs has been limited. WebMaurine E. Linder, Molecular Medicine, collaborating with the lab of Hening Lin, Chemistry and Chemical Biology, has identified a lipid modification, reversible lysine palmitoylation, that regulates Kras4A, a Ras isoform that’s broadly expressed in cancer cell lines and human colorectal tumors. They’ve found an enzyme that removes the ...
Lin, Boudker named Howard Hughes investigators - Cornell …
WebApr 3, 2013 · Hening Lin Nature 496 , 110–113 ( 2013) Cite this article 25k Accesses 526 Citations 33 Altmetric Metrics Abstract The Sir2 family of enzymes or sirtuins are known as nicotinamide adenine... WebHening Lin regularly links together related areas like Cell biology in his NAD+ kinase studies. His work in Nicotinamide adenine dinucleotide tackles topics such as … dr theut oam
The Lin Group - Cornell University
WebOct 8, 2024 · Researchers led by Hening Lin have found a new way to potentially treat inflammatory bowel disease, ... Lin’s group found that inhibiting this two-part lipid modification cycle in mice prevents the STAT3 protein from making its long journey to the nucleus, thereby suppressing inflammation and, ultimately, colitis, which is a form of IBD. ... WebMar 16, 2024 · Diphthamide is a posttranslationally modified histidine residue on archaeal and eukaryotic translation elongation factor 2 (EF2), a protein essential for ribosomal protein synthesis (1–3).Diphthamide biosynthesis involves at least four steps and seven proteins ().The first step of the biosynthesis is the transfer of a 3-amino-3-carboxypropyl (ACP) … WebHening Lin Small-molecule inhibitors of enzymes are widely used tools in reverse chemical genetics to probe biology and explore therapeutic opportunities. They are often … dr theva thevakumar