WebWe also complemented our Mu-Syc analysis with highest single agent (HSA) analysis for the same combinations of dasatinib + erlotinib, using cell growth rates ( Figure 3 F) and static cell counts ... Web24 de mai. de 2024 · HSA, highest single-agent. Consistent with broad efficacy, correlation analysis between patient sensitivity to the combination and standard clinical variables failed to reveal any significant associations (supplemental Figure 1). However, monocyte levels in peripheral blood revealed an opposing association for each single agent, ...
synergyfinder package - RDocumentation
Web13 de nov. de 2024 · For example, IBR+VEN showed enhanced efficacy in RCH-ACV B-ALL cells and showed synergy for the majority of drug-pair concentrations by the highest single agent (HSA) method (ibrutinib, venetoclax, and … Webhsa: Highest Single Agent model Description This function returns response levels for when these are based on Highest Single Agent (HSA) model. Usage hsa (doseInput, … nanother name for nail designer
hsa function - RDocumentation
Web13 de fev. de 2024 · 4.1 Drug synergy scoring. The synergistic effect can be determined as the excess of observed effect over expected effect calculated by a reference models (synergy scoring models). All of the models make different assumptions regarding the expected effect. Currently, 4 reference models are available in SynergyFinder. Web17 de mai. de 2024 · Most of the tools implement multiple reference models, including Bliss excess ( 22 ), Loewe additivity ( 23 ), highest single-agent (HSA) ( 24 ) and zero interaction potency (ZIP) ( 25) for synergy scoring. Web2 de jun. de 2010 · Using “Excess over Highest Single Agent” as a Screening Criterion •“Excess over Highest Single Agent” provides a low-level efficacy hurdle for combination drug screening. •“Excess over Highest Single Agent” provides the largest window for screening drugs for “dose reduction potential”. (A1,B1) combination A1 B1 Drug A nanothermtm