Terreic acid biosynthesis
Web1 Feb 2024 · Terreic acid is a potential anticancer drug as it inhibits Bruton’s tyrosine kinase; however, its biosynthetic molecular steps remain unclear. In this work, the individual … WebTerreic acid , CAS 121-40-4 (BVT-0477) is a high purity chemical isolated from Aspergillus terreus, beeing an antibiotic with antibacterial, anticancer (BTK inhibitor) and antioxidant …
Terreic acid biosynthesis
Did you know?
Web25 Sep 2024 · An A. terreus mutant strain was developed (gedCΔ) with a disrupted (+)-geodin biosynthesis pathway. The gedC Δ mutant was created by inserting the antibiotic … WebTerreic acid (TA) is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme MurA. The survival of most bacteria depends on the functionality of this cytosolic enzyme. The …
WebThe biosynthesis of (-)-terramutin is particularly relevant because this compound is a precursor of terreic acid, a potential anticancer drug capable of inhibiting Bruton's … WebTracer studies using the 14C-labeled salts of acetic acid, 6-methylsalicylic acid, and orsellinic acid demonstrate that the carbon skeleton of terreic acid (3,4-epoxy-6-hydroxy …
WebThese studies showed that the biosynthetic capacity of fungi is far greater than the molecules produced by them, and indicating the presence of untapped biosynthetic … WebSkip to main content. PNNL. About; News & Media; Careers; Events
WebThe individual reactions of terreic acid biosynthesis were determined by stepwise pathway assembly in a heterologous host on the basis of previous knockout studies in a native …
WebWhat is claimed is: 1. A population of heat-inducible macrophages, one or more of said heat-inducible macrophages comprising: a first inducible promoter operably linked to a first polynucleotide comprising a recombinase gene, wherein the first inducible promoter is capable of inducing transcription of the recombinase gene to generate a recombinase … oumc infectious diseaseWebTerreic acid is a potential anticancer drug as it inhibits Bruton's tyrosine kinase; however, its biosynthetic molecular steps remain unclear. In this work, the individual reactions of … rod sims anuWebABSTRACT: Terreic acid is a natural product derived from 6methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid. rod sims speechWeb8 Mar 2024 · Succinic acid, a dicarboxylic acid produced as an intermediate of the tricarboxylic acid (TCA) cycle, is one of the most important platform chemicals for the … rod simmons pigeonsWebThe biosynthesis of terreic acid. 1969 Nov. 5353932. Gas chromatographic analysis of the mycotoxins kojic acid, terreic acid, and terrein. 1970 May. 5424163. In vivo and in vitro … rod simpson gscWeb10 Apr 2014 · Terreic acid is commonly derived from 6-methylsalicylic acid. Isolating those compounds from Pseudocercospora sp. gave an indication that the biosynthesis pathway … rod sims icnWebNational Center for Biotechnology Information rod sightings